Protein Name:
Proliferating cell nuclear antigen
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UniprotKB/SwissProt ID: P12004 (P12004)
Gene Name:
PCNA
Organism: Homo sapiens (Human)
Function: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P12004
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
135 |
QLGIPEQEYS C VVKMPSGEFA |
CCCHHHHCHH H HHHHHHHHHH |
3.9% |
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| 2 |
148 |
KMPSGEFARI C RDLSHIGDAV |
CCCHHHHCHH H HHHHHHHHHH |
2% |
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| 3 |
162 |
SHIGDAVVIS C AKDGVKFSAS |
CCCHHHHCHH H HHHHHHHHHH |
3.61% |
22178444
19483679
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| 4 |
81 |
NLTSMSKILK C AGNEDIITLR |
CCCHHHHCHH H HHHHHHHHHH |
5.41% |
22178444
19483679
2212679
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