UniprotKB/SwissProt ID: P11881 (P11881)
Gene Name:
Itpr1
Organism: Mus musculus (Mouse)
Function: Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) and participates in calcium oscillations (PubMed:11955285, PubMed:12442173, PubMed:20813840, PubMed:2554142, PubMed:28416699, PubMed:35568199, PubMed:38099643). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as inositol 1,4,5-trisphosphate and Ca(2+), to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium, released from the ER, triggers apoptosis by the activation of CAMK2 complex (PubMed:19752026). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (PubMed:29907098). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (PubMed:38099643)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Cytoplasmic vesicle, secretory vesicle membrane. Cytoplasm, perinuclear region
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