Protein Name:
Cation-independent mannose-6-phosphate receptor
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UniprotKB/SwissProt ID: P11717 (P11717)
Gene Name:
IGF2R
Organism: Homo sapiens (Human)
Function: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane. Endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P11717
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
475 |
ACVKEKEDLL C GATDGKKRYD |
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| 2 |
531 |
RVLQEGKARG C PEDAAVCAVD |
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| 3 |
767 |
SYACPEEPLE C VVTDPSTLEQ |
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