Protein Name:
Ryanodine receptor 1
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UniprotKB/SwissProt ID: P11716 (P11716)
Gene Name:
RYR1
Organism: Oryctolagus cuniculus (Rabbit)
Function: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:10097181, PubMed:10388749, PubMed:12732639, PubMed:22036948, PubMed:26245150, PubMed:27662087, PubMed:3722165). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Sarcoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P11716
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1040 |
ATKRSNRDSL C QAVRTLLGYG |
CCCCCCCCCC E EEEECCCCHH |
2.56% |
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| 2 |
1303 |
LPVQFHQHFR C TAGATPLAPP |
CCCCCCCCCC E EEEECCCCHH |
2.75% |
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| 3 |
3635 |
SKQRRRAVVA C FRMTPLYNLP |
CCCCCCCCCC E EEEECCCCHH |
1.18% |
22036948
10601232
11562475
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