Protein Name:
Plasma membrane calcium-transporting ATPase 2
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UniprotKB/SwissProt ID: P11506 (P11506)
Gene Name:
Atp2b2
Organism: Rattus norvegicus (Rat)
Function: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (By similarity). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Synapse. Apical cell membrane. Basolateral cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P11506
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
487 |
DNNLVRHLDA C ETMGNATAIC |
CCCCCHHHHH C CCCCCCCCCC |
4.46% |
22178444
16418269
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| 2 |
497 |
CETMGNATAI C SDKTGTLTTN |
CCCCCHHHHH C CCCCCCCCCC |
3.9% |
22178444
16418269
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| 3 |
571 |
LPRQVGNKTE C GLLGFVLDLR |
CCCCCHHHHH C CCCCCCCCCC |
5.87% |
22178444
16418269
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