Protein Name:
Clathrin heavy chain 1
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UniprotKB/SwissProt ID: P11442 (P11442)
Gene Name:
Cltc
Organism: Rattus norvegicus (Rat)
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). Plays a role in early autophagosome formation (By similarity). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle membrane. Membrane, coated pit. Melanosome. Cytoplasm, cytoskeleton, spindle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P11442
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
151 |
MFDRHSSLAG C QIINYRTDAK |
CCCCCCCCHH H HHHHHCCCCC |
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22178444
16418269
18335467
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| 2 |
491 |
RANVPNKVIQ C FAETGQVQKI |
CCCCCCCCHH H HHHHHCCCCC |
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| 3 |
870 |
PWLEARIHEG C EEPATHNALA |
CCCCCCCCHH H HHHHHCCCCC |
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22178444
16418269
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| 4 |
918 |
YCEKRDPHLA C VAYERGQCDL |
CCCCCCCCHH H HHHHHCCCCC |
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| 5 |
926 |
LACVAYERGQ C DLELINVCNE |
CCCCCCCCHH H HHHHHCCCCC |
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