Protein Name:
Lysosome-associated membrane glycoprotein 1
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UniprotKB/SwissProt ID: P11438 (P11438)
Gene Name:
Lamp1
Organism: Mus musculus (Mouse)
Function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:15121881). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Also plays an important role in NK-cells cytotoxicity (PubMed:23847195). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (By similarity). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (By similarity). Also implicated in tumor cell metastasis (PubMed:2676155)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome membrane. Endosome membrane. Late endosome membrane. Cell membrane. Cytolytic granule membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P11438
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
327 |
LQATVGNSYK C NTEEHIFVSK |
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