Protein Name:
DNA topoisomerase 2-alpha
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UniprotKB/SwissProt ID: P11388 (P11388)
Gene Name:
TOP2A
Organism: Homo sapiens (Human)
Function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P11388
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
392 |
TLQPKSFGST C QLSEKFIKAA |
CCCCCCCCCC C CCCCCCCCCC |
4.03% |
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| 2 |
455 |
NDAGGRNSTE C TLILTEGDSA |
CCCCCCCCCC C CCCCCCCCCC |
3.67% |
24105792
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