Protein Name:
LINE-1 retrotransposable element ORF2 protein
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UniprotKB/SwissProt ID: P11369 (P11369)
Gene Name:
Pol
Organism: Mus musculus (Mouse)
Function: Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition (By similarity). Selectively binds and reversely transcribes RNA with a poly(A) tail consisting of at least 20 adenosines (By similarity). Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA (By similarity). Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to the sites of LINE-1 integration in the genome (By similarity). Conformational properties of the target DNA sequence rather than specific nucleotides are key determinants of the ORF2p capacity for sequence-specific DNA recognition (By similarity). Unlike related endonucleases, does not bend the DNA helix but causes compression near the cleavage site (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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