Protein Name:
Islet amyloid polypeptide
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UniprotKB/SwissProt ID: P10997 (P10997)
Gene Name:
IAPP
Organism: Homo sapiens (Human)
Function: Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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