Protein Name:
Thioredoxin
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UniprotKB/SwissProt ID: P10639 (P10639)
Gene Name:
Txn
Organism: Mus musculus (Mouse)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity) ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P10639
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
62 |
VVFLEVDVDD C QDVAADCEVK |
CCEECCCHHH H HHHHHHCCCC |
3.01% |
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| 2 |
69 |
VDDCQDVAAD C EVKCMPTFQF |
CCEECCCHHH H HHHHHHCCCC |
5.77% |
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| 3 |
73 |
QDVAADCEVK C MPTFQFYKKG |
CCEECCCHHH H HHHHHHCCCC |
4.82% |
20925432
21278135
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