Protein Name:
Microtubule-associated protein tau
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UniprotKB/SwissProt ID: P10636 (P10636)
Gene Name:
MAPT
Organism: Homo sapiens (Human)
Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P10636
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
639 |
PVDLSKVTSK C GSLGNIHHKP |
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37478858
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