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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Receptor-type tyrosine-protein phosphatase F

UniprotKB/SwissProt ID: P10586 (P10586)

Gene Name: PTPRF

Organism: Homo sapiens (Human)

Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTP_cat
IPR050713 RTP_Phos/Ushers
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 Tyr_Pase_dom

The S-nitrosylation sites of P10586

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1557 HCSAGVGRTG C FIVIDAMLER   
2 1582 KTVDIYGHVT C MRSQRNYMVQ   
3 1891 MVQTEDQYQL C YRAALEYLGS