Protein Name:
Apoptosis regulator Bcl-2
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UniprotKB/SwissProt ID: P10415 (P10415)
Gene Name:
BCL2
Organism: Homo sapiens (Human)
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P10415
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
158 |
VAFFEFGGVM C VESVNREMSP |
CCCCCCCCCC H HHHHHHHHHH |
2.6% |
22178444
16980304
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| 2 |
229 |
TLLSLALVGA C ITLGAYLGHK |
CCCCCCCCCC H HHHHHHHHHH |
1.69% |
22178444
16980304
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