UniprotKB/SwissProt ID: P0C5J4 (P0C5J4)
Gene Name:
Gpr52
Organism: Mus musculus (Mouse)
Function: G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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