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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Thiol peroxidase

UniprotKB/SwissProt ID: P0A862 (P0A862)

Gene Name: tpx

Organism: Escherichia coli (strain K12)

Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Has a preference for alkyl hydroperoxides and acts as a lipid peroxidase to inhibit bacterial membrane oxidation. Acts as a principal antioxidant during anaerobic growth

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Periplasm. Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR013740 Redoxin
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
IPR002065 TPX
IPR018219 Tpx_CS
IPR050455 Tpx_Peroxidase_subfamily

The S-nitrosylation sites of P0A862

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 82 ATEIDNTVVL C ISADLPFAQS  CCCEEEECCC E EEEECCCCCC  1.24% 22178444
19483679