Protein Name:
Small ribosomal subunit protein uS12
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UniprotKB/SwissProt ID: P0A7S3 (P0A7S3)
Gene Name:
rpsL
Organism: Escherichia coli (strain K12)
Function: With S4 and S5 plays an important role in translational accuracy Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P0A7S3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
27 |
AKSNVPALEA C PQKRGVCTRV |
CCCHHHHCCC H HHHHHHHHCC |
2.4% |
22178444
19483679
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