Protein Name:
Heterogeneous nuclear ribonucleoprotein A1
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UniprotKB/SwissProt ID: P09651 (P09651)
Gene Name:
HNRNPA1
Organism: Homo sapiens (Human)
Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233) (Microbial infection) May play a role in HCV RNA replication (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P09651
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
175 |
QKYHTVNGHN C EVRKALSKQE |
CCCCCCCCCH H HHHHHHHCCC |
4.19% |
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| 2 |
43 |
HFEQWGTLTD C VVMRDPNTKR |
CCCCCCCCCH H HHHHHHHCCC |
1.78% |
22178444
20140087
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