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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dihydrolipoyl dehydrogenase, mitochondrial

UniprotKB/SwissProt ID: P09624 (P09624)

Gene Name: LPD1

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Function: Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and the 2-oxoglutarate dehydrogenase complex, which catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:2821168). Also acts as a component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine (PubMed:7498764)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR050151 Class-I_Pyr_Nuc-Dis_Oxidored
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS