Protein Name:
Dihydrolipoyl dehydrogenase, mitochondrial
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UniprotKB/SwissProt ID: P09622 (P09622)
Gene Name:
DLD
Organism: Homo sapiens (Human)
Function: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Nucleus. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P09622
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
306 |
ASGGKAEVIT C DVLLVCIGRR |
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37478858
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| 2 |
312 |
EVITCDVLLV C IGRRPFTKNL |
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37478858
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| 3 |
477 |
AALALEYGAS C EDIARVCHAH |
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| 4 |
484 |
GASCEDIARV C HAHPTLSEAF |
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37478858
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| 5 |
85 |
TLGGTCLNVG C IPSKALLNNS |
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