Protein Name:
Phosphoglycerate kinase 1
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UniprotKB/SwissProt ID: P09411 (P09411)
Gene Name:
Pgk1
Organism: Mus musculus (Mouse)
Function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P09411
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
108 |
DCVGPEVENA C ANPAAGTVIL |
CCCCCCCCCC C CCCCCCEEEE |
5.92% |
24895380
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| 2 |
316 |
GIPAGWMGLD C GTESSKKYAE |
CCCCCCCCCC C CCCCCCEEEE |
9.75% |
21278135
|
| 3 |
367 |
DEVVKATSRG C ITIIGGGDTA |
CCCCCCCCCC C CCCCCCEEEE |
2.11% |
24895380
22588120
20925432
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| 4 |
379 |
TIIGGGDTAT C CAKWNTEDKV |
CCCCCCCCCC C CCCCCCEEEE |
1.65% |
24895380
22588120
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| 5 |
380 |
IIGGGDTATC C AKWNTEDKVS |
CCCCCCCCCC C CCCCCCEEEE |
3.66% |
24895380
22588120
20925432
|
| 6 |
50 |
IKAAVPSIKF C LDNGAKSVVL |
CCCCCCCCCC C CCCCCCEEEE |
3.86% |
24926564
21278135
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| 7 |
99 |
LGKDVLFLKD C VGPEVENACA |
CCCCCCCCCC C CCCCCCEEEE |
3.49% |
24895380
20925432
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