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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutathione S-transferase P

UniprotKB/SwissProt ID: P09211 (P09211)

Gene Name: GSTP1

Organism: Homo sapiens (Human)

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR050213 GST_superfamily
IPR036249 Thioredoxin-like_sf

The S-nitrosylation sites of P09211

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 102 MVNDGVEDLR C KYISLIYTNY  CCCEEEEEEE C CCHHHHHHHH  5.22%
2 48 TWQEGSLKAS C LYGQLPKFQD  CCCEEEEEEE C CCHHHHHHHH  3.97% 19483679
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