UniprotKB/SwissProt ID: P08962 (P08962)
Gene Name:
CD63
Organism: Homo sapiens (Human)
Function: Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Lysosome membrane. Late endosome membrane. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface
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