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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Small ribosomal subunit protein uS2

UniprotKB/SwissProt ID: P08865 (P08865)

Gene Name: RPSA

Organism: Homo sapiens (Human)

Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9 (Microbial infection) Acts as a receptor for the Dengue virus (Microbial infection) Acts as a receptor for the Sindbis virus (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus (Microbial infection) Acts as a receptor for the pathogenic prion protein (Microbial infection) Acts as a receptor for bacteria

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001865 Ribosomal_uS2
IPR032281 Ribosomal_uS2_C
IPR018130 Ribosomal_uS2_CS
IPR027498 Ribosomal_uS2_euk
IPR005707 Ribosomal_uS2_euk/arc
IPR023591 Ribosomal_uS2_flav_dom_sf
IPR027504 Ribosomal_uS2_vert

The S-nitrosylation sites of P08865

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 148 SYVNLPTIAL C NTDSPLRYVD   
2 163 PLRYVDIAIP C NNKGAHSVGL