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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Guanine nucleotide-binding protein G(i) subunit alpha-2

UniprotKB/SwissProt ID: P08752 (P08752)

Gene Name: Gnai2

Organism: Mus musculus (Mouse)

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001408 Gprotein_alpha_I
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase

The S-nitrosylation sites of P08752

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 140 RLWADHGVQA C FGRSREYQLN  CCCCCCHHHH H HHHHHHHHCH  1.76% 20925432
21278135
2 255 HESMKLFDSI C NNKWFTDTSI  CCCCCCHHHH H HHHHHHHHCH  5.48%
3 287 EKITQSSLTI C FPEYTGANKY  CCCCCCHHHH H HHHHHHHHCH  3.81%
4 326 DTKEIYTHFT C ATDTKNVQFV  CCCCCCHHHH H HHHHHHHHCH  3.62% 20925432
21278135
5 66 IHEDGYSEEE C RQYRAVVYSN  CCCCCCHHHH H HHHHHHHHCH  3.58% 20925432
21278135