Protein Name:
Integrin alpha-5
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UniprotKB/SwissProt ID: P08648 (P08648)
Gene Name:
ITGA5
Organism: Homo sapiens (Human)
Function: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973) (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19 (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell junction, focal adhesion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P08648
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
731 |
FAVNQSRLLV C DLGNPMKAGA |
CCCCCCCCCC C HHCCCCCCCC |
3.45% |
25040305
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