Protein Name:
Complement decay-accelerating factor
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UniprotKB/SwissProt ID: P08174 (P08174)
Gene Name:
CD55
Organism: Homo sapiens (Human)
Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829) (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5 (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable) (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell membrane. Secreted. Secreted. Secreted. Cell membrane. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P08174
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
FPVGTVVEYE C RPGYRREPSL |
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| 2 |
253 |
YGYRQSVTYA C NKGFTMIGEH |
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| 3 |
283 |
EGEWSGPPPE C RGKSLTSKVP |
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| 4 |
81 |
KIPGEKDSVI C LKGSQWSDIE |
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| 5 |
98 |
SDIEEFCNRS C EVPTRLNSAS |
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