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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Muscarinic acetylcholine receptor M2

UniprotKB/SwissProt ID: P08172 (P08172)

Gene Name: CHRM2

Organism: Homo sapiens (Human)

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Postsynaptic cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001065 Musac_Ach_M2_rcpt
IPR000995 Musac_Ach_rcpt