UniprotKB/SwissProt ID: P08100 (P08100)
Gene Name:
RHO
Organism: Homo sapiens (Human)
Function: Photoreceptor required for image-forming vision at low light intensity (PubMed:7846071, PubMed:8107847). Required for photoreceptor cell viability after birth (PubMed:12566452, PubMed:2215617). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:26200343, PubMed:28524165, PubMed:28753425, PubMed:8107847). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:26200343, PubMed:28524165)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Cell projection, cilium, photoreceptor outer segment
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