Protein Name:
Cathepsin B
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UniprotKB/SwissProt ID: P07858 (P07858)
Gene Name:
CTSB
Organism: Homo sapiens (Human)
Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome. Melanosome. Secreted, extracellular space. Apical cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P07858
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
211 |
EGDTPKCSKI C EPGYSPTYKQ |
CHHHHHHHHH H HHHHHCCCCC |
6.24% |
2212679
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| 2 |
319 |
FFKILRGQDH C GIESEVVAGI |
CHHHHHHHHH H HHHHHCCCCC |
8.7% |
25040305
37478858
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