Protein Name:
Annexin A2
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UniprotKB/SwissProt ID: P07356 (P07356)
Gene Name:
Anxa2
Organism: Mus musculus (Mouse)
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:22848640)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P07356
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
133 |
TDEDSLIEII C SRTNQELQEI |
CCCHHHHHHH H HCCCCCCCCC |
2.5% |
22588120
21278135
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| 2 |
262 |
LENAFLNLVQ C IQNKPLYFAD |
CCCHHHHHHH H HCCCCCCCCC |
2.42% |
20925432
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| 3 |
335 |
GDYQKALLYL C GGDD------ |
CCCHHHHHHH H HCCCCCCCCC |
3.46% |
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