UniprotKB/SwissProt ID: P07293 (P07293)
Gene Name:
CACNA1S
Organism: Oryctolagus cuniculus (Rabbit)
Function: Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163, PubMed:9465115). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:15201141, PubMed:27621462, PubMed:9465115). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane, sarcolemma, T-tubule
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