Protein Name:
Protein disulfide-isomerase
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UniprotKB/SwissProt ID: P07237 (P07237)
Gene Name:
P4HB
Organism: Homo sapiens (Human)
Function: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P07237
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
312 |
LEFFGLKKEE C PAVRLITLEE |
CHHHHHHHHH H HHHHHCCCCC |
2.48% |
22178444
20140087
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| 2 |
343 |
ELTAERITEF C HRFLEGKIKP |
CHHHHHHHHH H HHHHHCCCCC |
1.51% |
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| 3 |
397 |
NVFVEFYAPW C GHCKQLAPIW |
CHHHHHHHHH H HHHHHCCCCC |
2.31% |
22178444
16724068
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| 4 |
400 |
VEFYAPWCGH C KQLAPIWDKL |
CHHHHHHHHH H HHHHHCCCCC |
1.5% |
22178444
16724068
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| 5 |
53 |
YLLVEFYAPW C GHCKALAPEY |
CHHHHHHHHH H HHHHHCCCCC |
2.31% |
22178444
16724068
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| 6 |
56 |
VEFYAPWCGH C KALAPEYAKA |
CHHHHHHHHH H HHHHHCCCCC |
1.35% |
22178444
16724068
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