Protein Name:
Receptor-type tyrosine-protein phosphatase C
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UniprotKB/SwissProt ID: P06800 (P06800)
Gene Name:
Ptprc
Organism: Mus musculus (Mouse)
Function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane raft. Synapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P06800
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
339 |
IRRNTFIPER C QLDNLRAQTN |
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| 2 |
384 |
LGIPETPKPS C GDPAARKTLV |
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