Protein Name:
Alpha-enolase
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UniprotKB/SwissProt ID: P06733 (P06733)
Gene Name:
ENO1
Organism: Homo sapiens (Human)
Function: Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209) Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P06733
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
119 |
NAILGVSLAV C KAGAVEKGVP |
CCCEEEEEHH H HHCCCCCEEE |
1.76% |
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| 2 |
337 |
RIAKAVNEKS C NCLLLKVNQI |
CCCEEEEEHH H HHCCCCCEEE |
6.54% |
2212679
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| 3 |
339 |
AKAVNEKSCN C LLLKVNQIGS |
CCCEEEEEHH H HHCCCCCEEE |
3.12% |
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| 4 |
357 |
IGSVTESLQA C KLAQANGWGV |
CCCEEEEEHH H HHCCCCCEEE |
2.09% |
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| 5 |
389 |
TFIADLVVGL C TGQIKTGAPC |
CCCEEEEEHH H HHCCCCCEEE |
3.1% |
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| 6 |
399 |
CTGQIKTGAP C RSERLAKYNQ |
CCCEEEEEHH H HHCCCCCEEE |
8.08% |
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