Protein Name:
Uroporphyrinogen decarboxylase
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UniprotKB/SwissProt ID: P06132 (P06132)
Gene Name:
UROD
Organism: Homo sapiens (Human)
Function: Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:18004775, PubMed:21668429). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:21668429). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:12071824)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P06132
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
308 |
TVTLQGNLDP C ALYASEEEIG |
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| 2 |
35 |
GEETDYTPVW C MRQAGRYLPE |
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| 3 |
59 |
TRAAQDFFST C RSPEACCELT |
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| 4 |
65 |
FFSTCRSPEA C CELTLQPLRR |
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