UniprotKB/SwissProt ID: P05981 (P05981)
Gene Name:
HPN
Organism: Homo sapiens (Human)
Function: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, PubMed:21875933). Plays a role in cell growth and maintenance of cell morphology (PubMed:21875933, PubMed:8346233). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Apical cell membrane
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