UniprotKB/SwissProt ID: P05623 (P05623)
Gene Name:
SP
Organism: Drosophila melanogaster (Fruit fly)
Function: Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila (PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:20308537, PubMed:24089336, PubMed:3135120). Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors (PubMed:20308537, PubMed:20458515, PubMed:24089336). Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females (PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:24089336, PubMed:3135120)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
|
|
|
