Protein Name:
Integrin alpha-M
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UniprotKB/SwissProt ID: P05555 (P05555)
Gene Name:
Itgam
Organism: Mus musculus (Mouse)
Function: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane raft
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P05555
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
494 |
EKTRGGQVSV C PLPRGRARWQ |
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| 2 |
638 |
PKKVARSVFA C QEQVLKNKDA |
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