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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Lupus La protein
UniprotKB/SwissProt ID: P05455 (P05455)

Gene Name: SSB

Organism: Homo sapiens (Human)

Function: Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR045180 La_dom_prot
IPR006630 La_HTH
IPR014886 La_xRRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
The S-nitrosylation sites of P05455
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 18 EKMAALEAKI C HQIEYYFGDF  CCCCCCHHHH H HHHHHHHHHH  1.58%
2 232 EMKSLEEKIG C LLKFSGDLDD  CCCCCCHHHH H HHHHHHHHHH  4.6% 19483679
3 245 KFSGDLDDQT C REDLHILFSN  CCCCCCHHHH H HHHHHHHHHH  3.59%