Protein Name:
Intercellular adhesion molecule 1
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UniprotKB/SwissProt ID: P05362 (P05362)
Gene Name:
ICAM1
Organism: Homo sapiens (Human)
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P05362
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
457 |
VTRDLEGTYL C RARSTQGEVT |
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| 2 |
96 |
EDSQPMCYSN C PDGQSTAKTF |
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