UniprotKB/SwissProt ID: P05205 (P05205)
Gene Name:
Su(var)205
Organism: Drosophila melanogaster (Fruit fly)
Function: Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation (PubMed:26389589). Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:11859155, PubMed:26389589). Stabilizes chromatin-associated RNAs probably by binding to them and thereby preventing their degradation (PubMed:26389589). Associates with, and may be a part of, the HipHop-HOAP complex that recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion (PubMed:12510197, PubMed:20057353). Telomere capping is independent of the origin recognition complex (ORC) (PubMed:12510197)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus, nucleoplasm. Chromosome. Chromosome, telomere
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