Protein Name:
Aspartate aminotransferase, cytoplasmic
|
UniprotKB/SwissProt ID: P05201 (P05201)
Gene Name:
Got1
Organism: Mus musculus (Mouse)
Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P05201
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
160 |
AAGFKDIRPY C YWDAEKRGLD |
CCCCCHHCCC C CCCCEEEEEE |
2.84% |
21278135
|
| 2 |
253 |
YFVSEGFELF C AQSFSKNFGL |
CCCCCHHCCC C CCCCEEEEEE |
5.42% |
21278135
|
| 3 |
391 |
YLLPSGRINM C GLTTKNLDYV |
CCCCCHHCCC C CCCCEEEEEE |
3.32% |
21278135
|
| 4 |
83 |
PILGLAEFRS C ASRLVLGDNS |
CCCCCHHCCC C CCCCEEEEEE |
3.3% |
|
|
