Protein Name:
Sodium/potassium-transporting ATPase subunit beta-1
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UniprotKB/SwissProt ID: P05026 (P05026)
Gene Name:
ATP1B1
Organism: Homo sapiens (Human)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520) Involved in cell adhesion and establishing epithelial cell polarity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Apical cell membrane. Cell membrane, sarcolemma
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P05026
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
126 |
AQRDDMIFED C GDVPSEPKER |
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| 2 |
213 |
KYNPNVLPVQ C TGKRDEDKDK |
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