Protein Name:
Sodium/potassium-transporting ATPase subunit alpha-1
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UniprotKB/SwissProt ID: P05023 (P05023)
Gene Name:
ATP1A1
Organism: Homo sapiens (Human)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Basolateral cell membrane. Cell membrane, sarcolemma. Cell projection, axon. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P05023
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
211 |
ADLRIISANG C KVDNSSLTGE |
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| 2 |
249 |
TRNIAFFSTN C VEGTARGIVV |
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| 3 |
374 |
VETLGSTSTI C SDKTGTLTQN |
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| 4 |
459 |
GDASESALLK C IELCCGSVKE |
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| 5 |
463 |
ESALLKCIEL C CGSVKEMRER |
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| 6 |
464 |
SALLKCIELC C GSVKEMRERY |
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| 7 |
518 |
KGAPERILDR C SSILLHGKEQ |
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| 8 |
705 |
PQQKLIIVEG C QRQGAIVAVT |
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