Protein Name:
Major prion protein
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UniprotKB/SwissProt ID: P04925 (P04925)
Gene Name:
Prnp
Organism: Mus musculus (Mouse)
Function: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (PubMed:12732622, PubMed:16492732, PubMed:19242475, PubMed:19568430)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P04925
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
213 |
KMMERVVEQM C VTQYQKESQA |
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