Protein Name:
Anion exchange protein 2
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UniprotKB/SwissProt ID: P04920 (P04920)
Gene Name:
SLC4A2
Organism: Homo sapiens (Human)
Function: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Basolateral cell membrane. Apical cell membrane. Basolateral cell membrane. Apical cell membrane. Basolateral cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P04920
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1215 |
TRIFTDREMK C LDANEAEPVF |
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| 2 |
16 |
RRPAKGADSF C TPEPESLGPG |
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