Protein Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
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UniprotKB/SwissProt ID: P04843 (P04843)
Gene Name:
RPN1
Organism: Homo sapiens (Human)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR007676
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Ribophorin_I |
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The S-nitrosylation sites of P04843
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
477 |
PAAEARMKVA C ITEQVLTLVN |
CCCHHHHHHH H HHHCCCCCCC |
4.41% |
20140087
19483679
25040305
37478858
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| 2 |
545 |
SRLKTEGSDL C DRVSEMQKLD |
CCCHHHHHHH H HHHCCCCCCC |
3.64% |
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