Protein Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
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UniprotKB/SwissProt ID: P04035 (P04035)
Gene Name:
HMGCR
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Peroxisome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P04035
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
382 |
EPMLVRNNQK C DSVEEETGIN |
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