Protein Name:
Lytic switch protein BZLF1
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UniprotKB/SwissProt ID: P03206 (P03206)
Gene Name:
Organism: Epstein-Barr virus (strain B95-8) (HHV-4)
Function: Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (Probable) (PubMed:8404860). Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome (PubMed:15361873, PubMed:34893887). Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes (PubMed:30926617). Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (Probable) (PubMed:22022468, PubMed:34893887). Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells (PubMed:15361873, PubMed:19325883). BZLF1 and BRLF1 act together to trigger lytic replication (PubMed:10856251, PubMed:15361873). Also binds the lytic origin of replication, oriLyt (PubMed:20808903). Induces G1 cell cycle arrest by stabilizing the host CCAAT/enhancer binding protein CEBPA (PubMed:15078966). This function is important because the lytic cycle preferentially takes place in host cells arrested in G1 (PubMed:15078966)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Host nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P03206
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
189 |
RYKNRVASRK C RAKFKQLLQH |
CCCCCCCCCC C CCCCCCCCCC |
5.06% |
22178444
16227252
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